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Coaprovel 300/12.5mg Tablets 28's toys-r-us Retaining the revolutionary silhouette weCo Aprovel contains irbesartan 300 mg and hydrochlorothiazide 12. 5 mg. It is used in the treatment of high blood pressure. Irbesartan is an angiotensin receptor blocker (ARB). It works by blocking the hormone angiotensin thereby relaxing blood vessels. This allows the blood to flow more smoothly and the heart to pump more efficiently. Hydrochlorothiazide is a diuretic that removes extra water and certain electrolytes from the body. Over time it also